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The Effect of Cardiovascular Responses after Aerobic Exercise in Menstrual Cycle  [PDF]
Joonsung Park, Mi-Song Kim, Hosung Nho, Kyung-Ae Kim, Jong-Kyung Kim, Hyun-Min Choi
Health (Health) , 2017, DOI: 10.4236/health.2017.93030
Abstract: Purpose: We investigated the effect of menstrual cycle on the cardiovascular responses during recovery period from exercise. 10 healthy women were participated in the early follicular phase (EP: low estrogen and low progesterone: 1 - 4 days) and the late follicular phase (LP: high estrogen and low progesterone: 10 - 13 days) during menstrual cycle. Methods: All subjects completed a graded cycling exercise testing to determine the relative exercise intensity. All subjects were assessed systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total vascular conductance (TVC) at resting and during recovery period from moderated cycling exercise during EP and LP. Results: During EP, compared with LP, resting SBP and MAP were higher and TVC was lower (p < 0.05). During recovery from exercise, SBP and MAP were higher and TVC lower during EP compared with LP (p < 0.05). There were no differences in HR, SV and CO in both phases. Conclusions: This study could be increased the peripheral vasoconstriction in low estrogen levels. And during early follicular phase with low estrogen level, it may maintain an increased blood pressure during recovery period following cycling. We suggest that the timing of the menstrual cycle should be considered when measuring blood pressure during clinical exercise testing.
Characterization and function of human Ly-6/uPAR molecules
Hyun Kyung Kong & Jong Hoon Park*
BMB Reports , 2012,
Abstract: Human Ly-6/uPAR molecules are a superfamily composed oftwo subfamilies; one is the membrane bound proteins with aGPI-anchor and the other are secreted proteins without theGPI-anchor. Ly-6/uPAR molecules have remarkable amino acidhomology through a distinctive 8-10 cysteine-rich domain thatis associated predominantly with O-linked glycans. Thesemolecules are encoded by multiple tightly linked genes locatedon Chr. 8q23, and have a conserved genomic organization.Ly-6/uPAR molecules have an interesting expression patternduring hematopoiesis and on specific tumors indicating thatLy-6/uPAR molecules are associated with development of theimmune system and carcinogenesis. Thus, Ly-6/uPAR moleculesare useful antigens for diagnostic and therapeutic targets.This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well aswhat is known about their function in normal and malignanttissues and suggest Ly-6/uPAR molecules as target antigens forcancer immunotherapy.
Numerical Study on the Effects of Contraction Ratio in a Two-Phase Flow Injection Nozzle  [PDF]
Haider Ali, Kyung Won Kim, Jae Sik Kim, Jong Yun Choi, Cheol Woo Park
Open Journal of Fluid Dynamics (OJFD) , 2016, DOI: 10.4236/ojfd.2016.61001
Abstract: The Euler-Euler numerical method was used to investigate the effects of contraction ratio on twophase flow mixing with mass transfer in the flow injection nozzle. The geometric shape of the nozzle was modified to improve carbonation efficiency. A gas inlet hole was created to increase the flow mixing of CO2 with water. A nozzle throat was also introduced to increase the gas dissolution by increasing flow rates. Various contraction ratios of nozzle throat, inlet gas and liquid velocities, and gas bubble sizes were employed to determine their effects on gas hold-up, gas concentration, and mass transfer coefficient. Results revealed that the flow injection nozzle with high contraction ratios improved carbonation because of high gas hold-up. Gas concentration was directly related to contraction ratio and gas flow velocities. Carbonation reduced when high liquid velocities and large gas bubbles were employed because of inefficient flow mixing. This study indicated that flow injection nozzle with large contraction ratios were suitable for carbonation because of their ability to increase gas hold-up, gas concentration, and mass transfer coefficient.
Management Outcomes of Colonoscopic Perforations Are Affected by the General Condition of the Patients
Jae Ho Park,Kyung Jong Kim
- , 2018, DOI: 10.3393/ac.2018.34.1.16
Abstract: The management of a colonoscopic perforation (CP) varies from conservative to surgical. The objective of this study was to evaluate the outcomes between surgical and conservative treatment of patients with a CP
The Relationship between Thyroid Hormone Levels and Corrected QT Interval and QT Dispersion in Non-Diabetic Hemodialysis Patients  [PDF]
Heo-Yeong Kim, Ji Soo Kim, Seung Eun Suh, Yu Kyung Hyun, Kyeong Mi Park, Hyung-Jong Kim
Open Journal of Nephrology (OJNeph) , 2014, DOI: 10.4236/ojneph.2014.41003
Abstract:

Background: Cardiovascular disease and sudden cardiac death are common in hemodialysis patients. These cardiac complications are often associated with prolonged QTc interval (QTc) and QTc dispersion (QTcd). Subclinical hypothyroidism (SH) can alter autonomic modulation of heart rate and cause increased inhomogeneity of ventricular recovery time. We aimed to evaluate the relationship between thyroid hormone levels and QTc and QTcd in non-diabetic hemodialysis patients. Methods: We enrolled 29 non-diabetic hemodialysis patients without thyroid disease. After each hemodialysis session, a 12-lead ECG was recorded. Before each hemodialysis session, routine laboratory tests and measurement of thyroid hormone levels were performed. Patients were divided into 2 groups according to QTc (group 1 QTc < 430 ms, group 2 QTc ≥ 430 ms). We examined the relationship between QTc or QTcd and thyroid hormone in the respective groups and then compared the results from the 2 groups. Results: The mean age was 54.06 ± 14.72 years and the means of QTc and QTcd were 433.82 ± 22.03 ms, 59.10 ± 28.29 ms, respectively. Homocysteine levels were significant higher in group 2 than group 1 (p < 0.05) and QTcd was comparable between groups. In group 1, QTc and QTcd were not significant correlated with TSH, T3, fT4 and biochemical parameters. In group 2, QTc was significant positively correlated with TSH (p < 0.05) and QTcd was

The association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes
Jong Park, Min Cho, Chul Ahn, Kyung Kim, Kap Huh
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-62
Abstract: A total of 4,427 subjects with type 2 diabetes were enrolled in this study. Insulin sensitivity was assessed according the rate constant for plasma glucose disappearance (Kitt) determined via the short insulin tolerance test. Biochemical and anthropometric profiles were measured according to a standardized protocol. Visceral fat thickness and carotid intima media thickness (IMT) were measured by ultrasonography.Insulin sensitivity index (Kitt) was significantly correlated with weight adjusted thigh and calf circumference. Thigh circumference was inversely associated with IMT in men and women and calf circumference was negatively correlated with IMT in women. Multiple stepwise regression analysis revealed that thigh circumference was independently correlated with insulin sensitivity index (Kitt) and IMT. Furthermore, in multivariate logistic regression analysis, thigh circumference was an independent determinant factor for carotid atherosclerosis in patients with type 2 diabetes even after adjusting for other cardiovascular risk factors.Thigh and calf circumference were correlated with insulin resistance and carotid atherosclerosis, and thigh circumference was independently associated with insulin resistance and carotid atherosclerosis in patients with type 2 diabetes.Insulin resistance is associated with increased risk of cardiovascular disease (CVD), hypertension, obesity and dyslipidemia and is related to the development of type 2 diabetes [1]. Obesity, especially abdominal obesity, may play a major role in insulin resistance and various metabolic risk factors [2-6], however, recent studies have suggested that body muscle mass is also related to insulin resistance [1,7]. As skeletal muscle is an important site of glucose uptake and deposition [8], loss of muscle mass could influence insulin sensitivity and promote metabolic disorders such as diabetes mellitus [1]. Moreover recently, peripheral adiposity in lower body was found to be associated with insulin resista
The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production strategies
Kyung Lee, Jong Park, Tae Kim, Hongseok Yun, Sang Lee
Microbial Cell Factories , 2010, DOI: 10.1186/1475-2859-9-94
Abstract: The genome-scale metabolic model of Z. mobilis ZM4, ZmoMBEL601, was reconstructed based on its annotated genes, literature, physiological and biochemical databases. The metabolic model comprises 579 metabolites and 601 metabolic reactions (571 biochemical conversion and 30 transport reactions), built upon extensive search of existing knowledge. Physiological features of Z. mobilis were then examined using constraints-based flux analysis in detail as follows. First, the physiological changes of Z. mobilis as it shifts from anaerobic to aerobic environments (i.e. aerobic shift) were investigated. Then the intensities of flux-sum, which is the cluster of either all ingoing or outgoing fluxes through a metabolite, and the maximum in silico yields of ethanol for Z. mobilis and Escherichia coli were compared and analyzed. Furthermore, the substrate utilization range of Z. mobilis was expanded to include pentose sugar metabolism by introducing metabolic pathways to allow Z. mobilis to utilize pentose sugars. Finally, double gene knock-out simulations were performed to design a strategy for efficiently producing succinic acid as another example of application of the genome-scale metabolic model of Z. mobilis.The genome-scale metabolic model reconstructed in this study was able to successfully represent the metabolic characteristics of Z. mobilis under various conditions as validated by experiments and literature information. This reconstructed metabolic model will allow better understanding of Z. mobilis metabolism and consequently designing metabolic engineering strategies for various biotechnological applications.The impact of biotechnology on industry and society is dramatically gaining momentum, particularly in the field of agriculture-food, medicine and chemical production. For the chemical industry, which aims to producing value-added chemicals and fuels in a sustainable way, efforts have been put into strain improvement of microorganisms, utilizing many newly emergin
A Comparative Study on Isar Imaging Algorithms for Radar Target Identification
Jong-Il Park;Kyung-Tae Kim
PIER , 2010, DOI: 10.2528/PIER10071901
Abstract: Inverse synthetic aperture radar (ISAR) images represent the two-dimensional (2-D) spatial distribution of the radar cross-section (RCS) of an object and, thus, they can be applied to the problem of target identification. The traditional approach to ISAR imaging is the range-Doppler algorithm based on the 2-D Fourier transform. However, the 2-D Fourier transform often results in poor resolution ISAR images, especially when the measured frequency bandwidth and angular region are limited. Instead of the Fourier transform, high resolution spectral estimation techniques can be adopted to improve the resolution of ISAR images. These are the autoregressive (AR) model, multiple signal classification (MUSIC), and matrix enhancement and matrix pencil MUSIC (MEMP-MUSIC). In this study, the ISAR images from these high-resolution spectral estimators, as well as the FFT approach, are identified using a recently developed identification algorithm based on the polar mapping of ISAR images. In addition, each ISAR imaging algorithm is analyzed and compared in the framework of radar target identification. The results show that the dynamic range as well as the resolution of the ISAR images plays an important role in the identification performance. Moreover, the optimum size of the subarray (i.e. covariance matrix) for MUSIC and MEMP-MUSIC in terms of target identification is experimentally derived.
Effects of Schisandra chinensis fruit extract and gomisin A on the contractility of penile corpus cavernosum smooth muscle: a potential mechanism through the nitric oxide - cyclic guanosine monophosphate pathway
Bo Ram Choi,Hye Kyung Kim,Jong Kwan Park
- , 2018, DOI: 10.4162/nrp.2018.12.4.291
Abstract:
Penile Erection Induced by Scoparone from Artemisia capillaris through the Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Pathway
Bo Ram Choi,Hye Kyung Kim,Jong Kwan Park
- , 2017, DOI: 10.5534/wjmh.17023
Abstract:
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